Tissue-engineered nerve conduits with internal structure in the repair of peripheral nerve defects
10.3969/j.issn.2095-4344.2017.08.022
- VernacularTitle:神经导管内支架修复周围神经缺损的研究应用与进展
- Author:
Jun CHEN
;
Hua SHEN
- From:
Chinese Journal of Tissue Engineering Research
2017;21(8):1273-1279
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: To enhance peripheral nerve regeneration, the focus on the development of nerve conduits has been shifted from conventional conduits without internal structure to novel conduits with internal stuucture.Therefore, a comprehensive understanding of the internal structure of nerve conduits is necessary.OBJECTIVE: To review the application of tissue-engineered nerve conduits with internal structure in nerve regeneration.METHODS: A computer-based research of CNKI, WanFang, SinoMed and PubMed databases was performed to retrieve relevant literatures about the tissue-engineered nerve conduits with internal structure published from January 2009 to December 2015, using the keywords of nerve conduit/conduits/scaffolds/scaffold/channel/channels, internal scaffolds/scaffold, nerve regeneration/repair, hydrogel, acellularized/decellularized nerve in Chinese and English,respectively. Forty-seven eligible literatures were included for overview.RESULTS AND CONCLUSION: The novel nerve conduits with internal structure have many advantages over conventional conduits without internal structure, which can support, guide, promote peripheral nerve regeneration and functional recovery, especially, when modified with seed cells, neurotrophic factors or extracellular matrix, can achieve more effective results comparable to autologous nerve grafts.
