Alteration of Coagulation Function and Platelet Activation in Chronicity Stress Depression Model Rats and Effect of Electroacupuncture
10.3969/j.issn.1006-9771.2017.03.011
- VernacularTitle:慢性应激对大鼠凝血功能和血小板活化的影响及电针的干预作用
- Author:
Hongtao SONG
;
Zhong WU
;
Ruixia ZHANG
;
Chaoketu SAIYIN
;
Quankai JING
;
Haijiang YAO
- Publication Type:Journal Article
- Keywords:
depression;
electroacupuncture;
coagulation function;
platelet activation;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(3):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of coagulation function in chronic stress depression model rats and the effects of elec-troacupuncture (EA) on it. Methods A total of 32 Sprague-Dawley rats were randomly divided in control group (n=8), model group (n=8), EA group (n=8) and fluoxetine group (n=8) after a week of acclimation. The 21-day unpredictable mild stress combined with solitarily feed-ing was used to make the depression model in the latter three groups, meanwhile EA group and the fluoxetine group accepted EA and fluox-etine. They were measured the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). Serum levels of 6-keto-prostaglandin F1α(6-keto-PGF1α), P-selectin, thromboxane B2 (TXB2) were determined with enzyme-linked im-munoabsorbent assay. Results The cross and rear scores were significantly lower in the model group than in the control group (P<0.01). The scores increased in EA group and the fluoxetine group (P<0.01) compared with the model group. Compared with the control group, PT, APTT and TT decreased (P<0.01), FIB increased (P<0.05), the level of 6-keto-PGF1αdecreased, the level of P-selectin and TXB2 increased (P<0.01) in the model group. Compared with the model group, PT, APTT and TT increased (P<0.05), the level of 6-keto-PGF1αincreased (P<0.01), and the level of P-selectin and TXB2 decreased (P<0.05) in EA group and the fluoxetine group, and FIB decreased in EA group (P<0.05). Conclusion The chronic stress depression rats are impaired in the coagulation function and platelet activation, and can be allayed with electroacupuncture and fluoxetine.
