Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review)
10.3969/j.issn.1006-9771.2017.03.015
- VernacularTitle:缺氧诱导因子-1α在缺血性脑卒中模型中介导神经干-祖细胞作用机制的研究进展
- Author:
Dongyuan ZHANG
;
Ming LI
;
Zhengze WANG
;
Wenran ZHANG
;
Xiaodan XU
;
Liying ZHANG
;
Shen TIAN
- Keywords:
ischemic stroke;
hypoxia inducible factor-1α;
neural stem and progenitor cells;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(3):319-322
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor-1αis a kind of hypoxia response factor. Acute cerebral ischemia and anoxia can induce up-regula-tion of hypoxia inducible factor-1α, and the downstream genes, which plays a role in both the energy metabolism and collateral circulation after cerebral ischemia. Neural stem and progenitor cells regeneration also benefit the functional outcome after ischemic stroke. Hypoxia in-ducible factor-1αmay induce proliferation and differentiation of neural stem and progenitor cells through Notch, Wnt/β-catenin pathways, etc., in the ischemic stroke model.
