Effects of salicylate on dopamine levels in rat nucleus accumbens
10.16066/j.1672-7002.2017.03.011
- VernacularTitle:水杨酸钠作用后大鼠伏隔核内多巴胺水平变化
- Author:
Weini HU
;
Junxiu LIU
;
Lanqun MAO
;
Furong MA
- Keywords:
Animal Experimentation;
Sodium Salicylate;
Rats;
Tinnitus;
Dopamine;
nucleus accumbens;
microdialysis
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2017;24(3):153-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate dopamine level changes in the Nucleus Accumbens (NAc) of the limbic system by salicylate and the role of dopamine in the mechanisms of tinnitus.METHODS We recorded the change of dopamine before and after sodium salicylate injection in rats by microdialysis combined with electrochemical methodologies in the nucleus accumbens (NAc).RESULTS Salicylate produced significant increase in dopamine level in the NAc, to a maximum of (321±97)% of baseline and then remain stable. In contrast, saline only produced slight increase.CONCLUSION The increase of dopamine in the NAc may be related to the generation of tinnitus. The data in vivo provide direct evidence of the important role that the dopaminergic system plays in the generation of tinnitus.
