Serum Concentration Determination and Pharmacokinetics of Meropenem in Chinese Elderly Patients by HPLC
- VernacularTitle:老年患者美罗培南血药浓度监测结果分析及药物动力学研究
- Author:
Ting CHEN
;
Xiaohui HUANG
;
Jihui CHEN
;
Jia QI
;
Chun ZHANG
;
Jing MA
- Keywords:
Meropenem;
HPLC;
Pharmacokinetics;
Serum concentration
- From:
China Pharmacist
2017;20(3):402-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the concentration of meropenem in human serum and investigate its pharmacokinetics in Chi-nese elderly patients. Methods:Meropenem with single dose of 0. 5-1. 0 g was given to 25 elder patients by infusion administration. The concentration of meropenem was detected by an HPLC method. The pharmacokinetic parameters were calculated according to the pharmacokinetic model for adults and T>MIC was calculated by simple mathematical simulation. Results: The major pharmacokinetics parameters were as follows:Cmax of (46. 2 ± 24. 4) μg·ml-1;t1/2 of (3. 3 ± 1. 8) h,CL of (8. 7 ± 5. 0) L·h-1 ,V of (9. 8 ± 1. 3) L and AUC of (148. 2 ± 75. 4)μg·h·ml-1 . Compared with that of the healthy subjects reported in the literatures, t1/2 significantly pro-longed, V significantly decreased and AUC significantly increased (P<0. 01). Conclusion: The pharmacokinetics of meropenem in elder patients is significantly different from the healthy subjects. The clinical application should pay attention to monitoring the blood concentration of meropenem.
