Study progress of Tacrolimus treatment on steroid-resistant nephrotic syndrome in children
10.3760/cma.j.issn.2095-428X.2017.05.020
- VernacularTitle:他克莫司治疗儿童激素抵抗型肾病综合征研究进展
- Author:
Jiayi ZHANG
;
Suling WEI
;
Shumin RUI
;
Zhengkun XIA
;
Chunlin GAO
- Keywords:
Tacrolimus;
Child;
Steroid-resistant;
Idiopathic nephrotic syndrome
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(5):392-395
- CountryChina
- Language:Chinese
-
Abstract:
Steroid-resistant nephrotic syndrome (SRNS) is a relatively difficult clinical type of treatment.The major therapy measures in present include steroid and immunosuppressant.Commonly used immunosuppressant include tacrolimus,cyclosporin,cyclophosphamide,mycophenolate mofetil,ect.Tacrolimus-induced clinical remission rate is superior to other immunosuppressive agents,has been the first-line agent of SRNS.Because of the individual difference in metabolism,the drug concentration of tacrolimus should be determined periodically.In order to obtain optimal efficacy of tacrolimus and reduce renal toxicity,the treatment protocols of small doses with long courses for children with SRNS were recommended.
