Research progress of CX3CL1-CX3CR1 and the pathogenesis of sepsis
10.11958/20170042
- VernacularTitle:CX3CL1-CX3CR1与脓毒症发病机制的研究进展
- Author:
Dingwei PENG
;
Yueqiu QIN
;
Pinhu LIAO
- Keywords:
sepsis;
chemokine CX3CL1;
receptors;
CXCR;
review
- From:
Tianjin Medical Journal
2017;45(4):428-431
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis has poor prognosis, and its pathogenesis is not clear. Chemokine CX3CL1 (Fractalkine, FNK) has many functions such as chemotaxis, adhesion and mediate immune injury. CX3CR1 is the only receptor of CX3CL1 and participates in the development of sepsis. Here we review the structure, biological function and possible mechanism of CX3CL1 and CX3CR1 in the pathogenesis of sepsis.
