Role of Microglia in Damage after Ischemic Stroke (review)
10.3969/j.issn.1006-9771.2017.01.010
- VernacularTitle:缺血性脑卒中后小胶质细胞损伤作用的研究进展
- Author:
Dong WANG
;
Boru HOU
;
Wenzhen YANG
;
Junlin KANG
;
Haijun REN
- Keywords:
ischemic stroke;
microglia;
injury;
receptors;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Microglial cells are the resident immune cells of brain. The activated microglia produces a range of deleterious substances, which plays an important role in the inflammation of post-stroke, such as superoxide, nitric oxide, matrix metalloproteinases, etc. The activa-tion of microglia may involve triggering receptor expressed on myeloid cells-1, Toll-like receptors 4, peroxisome proliferator-activated re-ceptors, purinergic receptors, etc. Intervention targeted to microglial receptor is becoming a new strategy for ischemic stroke.
