Establishment of malignant pleural effusion model of Lewis lung cancer based on Micro Echo Technology
10.3969/j.issn.1005-1678.2017.02.002
- VernacularTitle:基于小动物超声的小鼠Lewis肺癌胸腔积液模型的建立
- Author:
Hanze YANG
;
Chunyang WANG
;
Yue CHEN
;
Ming JI
;
Xiaoguang CHEN
- Keywords:
lung cancer;
pleural effusion;
Micro Echo Technology
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a malignant pleural effusion model of Lewis lung cancer in C57BL/6 mice based on Micro Echo technology. Methods Single tumor cell suspension of Lewis lung cancer was injected into thoracic cavity.The pleural effusion was detected by Micro Echo technology.The volumes of effusion were quantified and the tumor cells were counted.Results After implanted of tumor cell, malignant pleural effusion can be detected by Micro Echo technology and observed after autopsy.Chemotherapy drugs such as Cyclophosphamide and Cisplatin can decrease the effusion volumes.Conclusion Pleural effusion model of Lewis lung cancer based on Micro Echo technology can be used to evaluate the efficacy of antitumor drugs.
