Therapeutic effect of tripterysium glycosides combined with isotretinoin in cysticacne and its effect on related indicators
10.3969/j.issn.1005-1678.2017.02.021
- VernacularTitle:雷公藤多苷联合异维A酸治疗囊肿型痤疮患者的疗效及对相关因子的影响
- Author:
Yuhua ZHANG
;
Wenhui HUANG
- Keywords:
tripterysium glycosides tablets;
isotretinoin capsule;
cysticacne;
efficacy;
inflammatory factors;
IGF-1;
DHEA
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of tripterysium glycosides combined with isotretinoin in cysticacne and its effect on serum inflammatory factors, insulin like growth factor 1 (IGF-1) and dehydroepiandrosterone (DHEA).Methods 118 cases of cysticacne patients were divided into observation group (n=59) and control group (n=59) according to the random number table method.Patients in the control group were treated with isotretinoin capsule, while the observation group were treated with tripterysium glycosides tablets on the basis of the control group.The course of treatment was 8 weeks in two groups.Results The total efficiency of the observation group (89.83%) was higher than the control group (71.19%) (P<0.05); the number of cyst after treatment in the observation group were less than the control group (P<0.05);the serum IL-2 and IL-4 levels in the observation group after treatment reduced, and lower than the control group (P<0.05);the serum IGF-1 and DHEA levels in the observation group after treatment reduced, and lower than the control group (P <0.05); the recurrence rate of the observation group (11.86%) was lower than the control group (30.51%) (P<0.05);the adverse reactions in two groups had no statistically significant.Conclusion Tripterysium glycosides combined with isotretinoin capsule has obvious curative effect in the treatment of cysticacne patients, and can reduce the serum IL-2, IL-4 levels and IGF-1 and DHEA levels, with lower recurrence rate, fewer adverse reactions.
