Effect of calcium dobesilate tablets combined with mecobalamin injection on diabetic peripheral neuropathy and its effects on oxidative stress and neurotrophic factor
10.3969/j.issn.1005-1678.2017.02.057
- VernacularTitle:羟苯磺酸钙片联合甲钴胺注射液治疗糖尿病周围神经病变的疗效观察及对氧化应激和神经营养因子的影响
- Author:
Jiayong DAI
;
Guifen YU
;
Wei CHEN
;
Xianyong DAI
;
Yan WANG
;
Jixin LI
- Keywords:
calcium dobesilate tablets;
mecobalamin injection;
diabetic peripheral neuropathy;
curative effect;
oxidative stress;
neurotrophic factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):187-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the calcium dobesilate tablets combined with mecobalamin injection in treatment of diabetic peripheral neuropathy and effects on oxidative stress and neurotrophic factor.Methods 82 cases of diabetic peripheral neuropathy(DPN) patients from February 2015 to October 2016 in our hospital were selected and randomly divided into observation group and control group with 41 cases in each group.The control group was treated with mecobalamin injection, the observation group were treated with calcium dobesilate tablets.The course of treatment was two weeks in two groups.Results The total efficiency of the observation group (90.24%) was higher than the control group (68.29%) , the difference was statistically significant ( P<0.05 ) , patients in the observation group after the treatment of common peroneal nerve and median nerve SCV and MCV higher than the control group, the difference was statistically significant (P <0.05), the level of serum malondialdehyde (MDA) in the observation group was lower than that in the control group and the level of superoxide dismutase ( SOD) in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05), the levels of serum NGF and BDNF in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05), the two groups were no obvious adverse reactions.Conclusion Calcium dobesilate tablets and mecobalamin injection curative effect in the treatment of diabetic peripheral neuropathy , and patients could improve oxidative stress and neurotrophic factors, and the safety is good, has the important research significance.
