Clinical efficacy and safety of oxycodone hydrochloride controlled-release tablets in treatment of advanced cancer pain
10.3969/j.issn.1005-1678.2017.02.061
- VernacularTitle:盐酸羟考酮控释片治疗晚期癌症疼痛患者的临床疗效及安全性分析
- Author:
Yue LIU
;
Shuning YAN
;
Yanling WANG
;
Hongyan WANG
;
Shaozhao WU
;
Jianlei ZHU
- Keywords:
oxycodone hydrochloride controlled-release tablets;
treatment outcome;
clinical efficacy;
sfety
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):199-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of oxycodone hydrochloride controlled-release tablets in treatment of advanced cancer pain.Methods 130 patients with advanced cancer pain were selected and randomly divided into two groups,65 patients received oxycodone hydrochloride controlled-release tablets as observation group,65 patients received morphine sulfate controlled-release tablets as control group.Quality of life score was evaluated, clinical efficacy and safety were compared between two groups.Results After treatment, cancer pain of patients in two groups were relieved than pre-treatment (P<0.05), and patients in observation group were better than control group (P<0.05).After treatment, the quality of life in two groups were all improved ( P <0.05 ) , and patients in observation group was more obvious than control group ( P <0.05 ) .During the treatment, adverse reactions occurred in different degrees, and the incidence of adverse reactions in the observation group was lower than control group (P<0.05).Conclusion Oxycodone hydrochloride controlled-release tablets are effective drug in treatment of advanced cancer pain,which can significantly relieve pain and improve quality of life.
