Research progress of extraction and purification of Hirudin
10.3969/j.issn.1005-1678.2017.02.098
- VernacularTitle:水蛭素提取纯化研究进展
- Author:
Sheng HUANG
;
Wei XIONG
;
Junjie YAO
;
Lu LI
;
Hongdiao CHEN
;
Yinhuan YANG
;
Hongjun YAO
- Keywords:
Hirudin;
extraction;
purification
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):313-315
- CountryChina
- Language:Chinese
-
Abstract:
Hirudin as a novel anticoagulant and antithromotic agent, is a kind of protein that is obtained from the salivary gland secretion of one kind blood-sucking leech.It increases the difficulty extraction and purification of hirudin that composition of no anticoagulant activity of peseudo-hirudin in the body of leech and a large number of complex material from the salivary gland secretion of one kind blood-sucking leech.This article focuses on reviewing the structure of hirudin, genetic makeup, extraction and purification of hirudin according to the related research.Analysis of the pros and cons of various extraction and purification methods.Looking forward to its developing tendency, so as to provide reference for extraction and purification of Hirudin.
