The Meta-analysis on efficacy and safety of Eszopiclon and Alprazolam in the treatment of insomnia
10.7652/jdyxb201702023
- VernacularTitle:右佐匹克隆对比阿普唑仑治疗失眠症疗效和安全性的Meta分析
- Author:
Li WANG
;
Yanan XUE
;
Rui XU
;
Bei ZHANG
- Keywords:
Eszopiclon;
Alprazolam;
insomnia;
Meta-analysis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(2):274-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To make a systematic evaluation of the efficacy and safety of Eszopiclon and Alprazolam in the treatment of insomnia.Methods By searching the PubMed,Cochrance Library,CNKI, WANFANG,and VIP database,we studied the literature published between 2005 to 2016 on the efficacy and safety of Eszopiclon and Alprazolam in the treatment of insomnia.We collected the randomized controlled trials (RCTs), evaluated the quality of methods and then analyzed the data using RevMan5.3 software.Results A total of 18 RCTs were included,involving 2088 patients.According to Meta-analysis,Eszopiclon group had a significantly higher total efficacy rate [RR=1.07,95% CI (1.02,1.11),P=0.003],lower severity of adverse reactions [MD=-0.43,95% CI(-0.75,-0.12),P=0.008]and incidence of adverse reactions [RR=0.46,95% CI(0.32, 0.66),P<0.0001]than Alprazolam group.However,the two groups did not significantly differ in sleep quality scores after 4-week teatment [MD=-0.05,95% CI(-0.22,0.12),P=0.54].Conclusion Eszopiclon is more effective on insomnia than Alprazolam,with better safety,and it deserves wide clinical use.
