Effects of radix notoginseng saponin dispersible tablets combined with rivaroxaban in treatment of tibial fracture after operation and its effects on joint function and the leves of inflammatory factors
10.3969/j.issn.1005-1678.2017.02.022
- VernacularTitle:血塞通分散片联合利伐沙班对胫骨骨折患者术后关节功能及炎症因子水平的影响
- Author:
Hongguang JIN
;
Yongge BAO
;
Yuxiang BAO
;
Wei ZHANG
- Keywords:
tibial fracture;
radix notoginseng saponin dispersible tablets;
Rivaroxaban;
joint function;
inflammatory factors
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):75-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study curative efficacy of radix notoginseng saponin dispersible tablets combined with rivaroxaban in treatment of tibial fracture after operation and its effects on joint function and the leves of inflammatory factors .Methods 90 patients of tibial fracture who received therapy from March 2014 to March 2016 in our hospital were selected.According to random number table,all elective surgery,those patients were divided into the observation group (n=45) and the control group (n=45),the control group was treated with radix notoginseng saponin dispersible tablets,while the observation group was treated combined with rivaroxaban.After two weeks of treatment, the hemorheology, inflammatory factors, joint function were compared between two groups.Results The patient swelling time and bed time in the observation group were shorter than the control group (P<0.05);after treatment,the levels of red cell volume, whole blood viscosity,fibrinogen in the observation group were lower than the control group (P<0.05);the levels of tumor necrosis factor TNF-α, IL-1,IL-6 in the observation group were lower than the control group (P<0.05);after treatment three months and six months,the Baird-Jackson scores in the observation group were higher than the control group (P <0.05).Conclusion Radix notoginseng saponin dispersible tablets combined with rivaroxaban is well for tibial fracture after operation,which can improve hemorheology,reduce the level of inflammatory factors,promote joint functional recovery.
