Clinical efficacy of Roukouwuweiwan in treatment of schizophrenia and its effect on serum SOD, MDA and NO
10.3969/j.issn.1005-1678.2017.02.029
- VernacularTitle:肉蔻五味丸治疗精神分裂症患者的临床疗效及对血清SOD、MDA、NO的影响
- Author:
Li ZHANG
;
Peng XIAO
- Keywords:
Roukouwuwei Wan;
schizophrenia;
superoxide dismutase;
malondialdehyde;
nitric oxide
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(2):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of Roukouwuwei Wan in the treatment of schizophrenia and its effect on serum superoxide dismutase, malondialdehyde and nitric oxide.Methods 84 cases of patients with schizophrenia were enrolled in our hospital from September 2015 to June 2016,according to coin-casting method divided into observation group and control group,42 cases in each group.The control group was treated with conventional regimen, and the observation group was treated with Rouku Wuwei Pills on the basis of control group.The quality of life, serum SOD, MDA and NO were measured before and after treatment,the clinical efficacy and side effects were analyzed.Results After treatment, the total effective rate of the observation group was significantly higher than the control group (P<0.05).After treatment,the scores of physical life,social function,mental health and physical health of the observation group were significantly higher than the control group ( P <0.05 );The levels of superoxide dismutase, malondialdehyde and nitric oxide in the observation group were significantly lower than the control group (P<0.05).The adverse reaction rate in the observation group was significantly lower than the control group (P<0.05).Conclusion The treatment of schizophrenia patients with Roukouwuwei Wan can reduce the levels of SOD,MDA and NO, improve the quality of life of patients, the clinical efficacy is good and reduce the incidence of adverse reactions.
