Mitochondria abnormality and pulmonary arterial hypertension
10.16571/j.cnki.1008-8199.2017.02.021
- VernacularTitle:线粒体在肺动脉高压发生中的研究进展
- Author:
Xinpei WANG
;
Zhenhua LIU
- Keywords:
Pulmonary arterial hypertension;
Mitochondria;
Metabolism
- From:
Journal of Medical Postgraduates
2017;30(2):204-207
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary arterial hypertension ( PAH) is a progressive lethal vascular disease, which is characterized by pulmo-nary vasoconstriction and vascular remodeling. Recent studies have indicated that the metabolic theory, centered on the loss of mito-chondrial function, plays a key role in the occurrence and development of PAH. This theory links mitochondrial-related changes of ap-optosis-resistance, glycolysis enhancement, mROS decrease and aberrant mitochondrial dynamics to multiple molecular abnormalities, which may provide new ideas for exploring more comprehensive and specific treatment strategies. This article reviews the progresses in mitochondrial abnormality in PAH.
