Characteristics and functions of microglia:Advances in studies

VernacularTitle:小胶质细胞特性及其功能的研究进展
Author: Qiong ZHANG ; Wenjuan LIU
Keywords: Microglia; Central nervous system; Characteristics; Function
From: Journal of Medical Postgraduates 2017;30(2):216-219
CountryChina
Language:Chinese
Abstract: Microglia are functionally principal immune effector cells widely spread in the central nervous system ( CNS) and physiological play a role in monitoring and stabilizing the internal environment. Very sensitive to external stimulation, microglia are eas-ily activated by slight pathological changes in the CNS. The activated microglia, on the one hand, phagocytize cellular debris and ex-crete growth factors to promote nerve repair and, on the other hand, also produce some inflammatory cytokines, glutamate, and nitric oxide, which may aggravate the inflammatory response and lead to secondary injury. This article summarizes the characteristics of mi-croglia and their involvement in CNS diseases and provides a new target for their treatment.