Research progress in biomarkers of pulmonary fibrosis diseases

VernacularTitle:肺纤维化疾病生物标志物的研究进展
Author: Ming CHEN ; Ming ZENG ; Xingxuan HE
Keywords: lungs; fibrosis; biomarkers
From: Chinese Journal of Pharmacology and Toxicology 2017;31(2):187-194
CountryChina
Language:Chinese
Abstract: Pulmonary fibrosis is a group of chronic lung diseases induced by various causes. Because of its complex etiology and pathogenesis,most of the pulmonary fibrosis diseases have no effective treatment currently and the quality of life and prognosis of patients are poor. Recent studies on biomarkers of susceptibility and effect associated with pulmonary fibrosis have made great progress, which is of great significance for screening and early diagnosis of the disease,and even for the evaluation of therapeutic efficacy and prognosis. This paper reviews some potential biomarkers of pulmonary fibrosis diseases,including the mucin 5B promoter variant and matrix metalloprotease-7 associated with idiopathic pulmonary fibrosis,heme oxygenase-1 and serum Se related to silicosis,Krebs von den Lungen-6,surfactant proteins-D and sphingolipids signaling associated with various pulmonary fibrosis, in order to provide new ideas for further research on the prevention and treatment of pulmonary fibrosis diseases.