Signaling pathways inducing embryonic stem cells to differentiate into epidermal and corneal epithelial cells

VernacularTitle:胚胎干细胞向体表外胚层及角膜上皮细胞分化过程中信号通路的调节
Author: Lulu HOU ; Yifei HUANG
Keywords: embryonic stem cells; ectoderm; corneal epithelial cell; signaling pathway
From: Chinese Journal of Pharmacology and Toxicology 2017;31(2):195-202
CountryChina
Language:Chinese
Abstract: Stem cells are a group of self-renewal cells with the potential to differentiate into a variety of cell lineages. Embryonic stem cells can differentiate into more than 200 types of cell lineages belonging to endodermal, mesodermal and ectodermal tissues. Corneal epithelial cells derive from epidermal ectoderm during embryonic development. When the ocular surface is severely damaged, corneal epithelium with proliferation potential is essential for its reconstruction. Recent studies are focused on differentiation of bioactive corneal epithelial cells. This review summarizes signaling pathways including Notch, Wnt, bone morphogenetc protein or fibroblast growth factor pathways that are involved in regu?lating the development of embryonic ectoderm and corneal epithelial cells revealed in previous studies.