Research the relationship between vasodilator-stimulated-phosphoprotein and risk factors for atherosclero-sis
10.16571/j.cnki.1008-8199.2017.02.023
- VernacularTitle:血管扩张刺激磷蛋白与动脉硬化危险因素的关系研究进展
- Author:
Yan JIA
- Keywords:
Vasodilator-stimulated-phosphoprotein;
Atherosclerosis;
cGMP-dependent protein kinase
- From:
Journal of Medical Postgraduates
2017;30(2):212-215
- CountryChina
- Language:Chinese
-
Abstract:
In the past few decades, accumulated experimental and clinical evidences suggest that cyclic guanosine monophos-phate (cGMP) plays an important role in atheroselerosis. Vasodilator-stimulated phosphoprotein (VASP), a major downstream compo-nent of the cGMP signaling cascade, is an actin-binding protein which regulates cell adhesion, morphology change, cell motility and cell proliferation. It has shown that VASP is associated with many factors influencing atherosclerosis, and it plays an important role in the genesis and development of atherosclerosis. The relationships between the occurrence of atherosclerosis and risk factors for athero-sclerosis such as hypertension, hyperglycaemia and hyperlipidemia are reviewed in this article.
