Study of the sensitivity and specificity on near-infrared spectroscopy in diagnosis of depression

VernacularTitle:近红外光成像技术辅助诊断抑郁症的灵敏度和特异度研究
Author: Ju TIAN ; Wenxiang QUAN ; Jiuju WANG ; Pengfei WANG ; Jin LIU ; Wentian DONG
Keywords: Near-infrared spectroscopy; Depression; Verbal fluency test; Sensitivity; Spe-cificity
From: Chinese Journal of Behavioral Medicine and Brain Science 2017;26(2):149-152
CountryChina
Language:Chinese
Abstract: Objective To explore the sensitivity and specificity of near-infrared spectroscopy ( NIRS) in the diagnosis of depression. Methods From March 2013 to August 2013,62 patients with de-pression and 70 normal controls were collected from Peking University Sixth Hospital. Optical Tomography System (52 channels) was used to collect the NIRS data during the Verbal Fluency Test (VFT),and the number of words produced during VFT task was recorded. The wave analysis was performed by a professional psychiatrist. Results There was statistical difference in the number of words produced during VFT task be-tween the patients with depression (8.65±0.49)and control group(10.19±0.43) ( t=2.385, P<0.05). Through the wave analysis of NIRS to test patients with depression,the results demonstrated that the sensitivi-ty was 66.1% and the specificity was 91.4%. Conclusion The results of NIRS test display high specificity in the diagnosis of depression,which can be used as an objective index for clinical auxiliary diagnosis.