Amorolfine Nail Lacquer 5 % Once Weekly in Onychomycosis of Fingers and / or Toes.
- Author:
Hee Chul EUN
;
My Hyoung LEE
;
Soo Nam KIM
;
Hee Joon YOO
;
Kyung Sool KWON
;
Soo Chan KIM
;
Jae Seung LEE
;
Bang Soon KIM
;
Byoung Soo CHUNG
;
Seung Ho CHANG
;
Chun Wook PARK
- Publication Type:Original Article
- Keywords:
Amorolfine;
Nail Lacquer;
Onychomycosis;
Treatment
- MeSH:
Fingers*;
Humans;
Lacquer*;
Onychomycosis*;
Toes*
- From:Korean Journal of Dermatology
1995;33(2):314-321
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Amorolfine is a new topical antifungal drug of the morpholine class has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period. OBJECTIVE: The aim of this study is to assess the efficacy and tolerability of 5% amorolfine nail lacquer given once weekly to the patients with onychomycosis. METHODS: 29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment. RESULTS: Average affected area(%) and average score of clinical signs-thickening, splitting, discoloration-were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients.No systemic or local side effect was observed. CONCLUSION: Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.
