Successful Treatment of an Infant with Kasabach - Merritt Syndrome with Interferon Alfa - 2a.
- Author:
Jung Ho YOON
;
Ki Ho KIM
;
Gwang Yeol JOH
- Publication Type:Case Report
- Keywords:
Kasabach-Merritt Syndrome;
Interferon Alfa-2a
- MeSH:
Abdomen;
Anemia, Hemolytic;
Female;
Hemangioma;
Humans;
Infant*;
Interferon-alpha*;
Interferons*;
Kasabach-Merritt Syndrome;
Leg;
Parturition;
Plasma;
Platelet Count;
Prednisolone;
Prothrombin Time;
Thrombocytopenia
- From:Korean Journal of Dermatology
1995;33(2):363-368
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kasabach- Merritt syndrame consists of thrombocytopenia, microangiopathic hemolytic anemia, and an acute or chronic censumptive coagulopathy in associati an with a rapidly enlarging hemangioma. Most vascular turrnrs causing Kasabach-Merritt syndon e are benign but the associated coagulopathy may be lifethreatening. Our patient, a 30-day-old female infant, was admitted after an increase in the size of a hemangioma present since birth on the right leg with extension to the lower abdomen and left inguinal area. Her herrnglobin count fell to 7.1g/dl, platelet count was 26,000/ul, prothrombin time was 26 seconds, and hypofibrinogenemia developed. The patient was treated with transfusions of platelets, fresh frozen plasma and red cells and prednisolone. for 2 weeks without improvement. We started interferon alfa-2a therapy. Over the past 6 months, he hemangioma progressively diminished in size withcut any serious complication.
