Association between Ubiquitin-specific Proteases 24 Gene Polymorphisms and Sporadic Parkinson's Disease in the Han Guangdong Population

VernacularTitle:泛素特异性蛋白酶24基因多态性与广东汉族人群散发性帕金森病的关系
Author: Zhijun LIN ; Yusen CHEN ; Wangtao ZHONG ; Zhou LIU ; Wenchuan XIAN ; Xiaoyi CHEN ; Bin ZHAO
Keywords: ubiquitin-specific proteases 24; Parkinson's disease; gene polymorphisms
From: Chinese Journal of Rehabilitation Theory and Practice 2017;23(3):345-348
CountryChina
Language:Chinese
Abstract: Objective To explore the association of ubiquitin-specific proteases 24 (USP24) gene polymorphisms with susceptibility to sporadic Parkinson's disease (PD) in the Han Guangdong population. Methods From August, 2006 to January, 2014, single nucleotide poly-morphisms (SNPs) of rs12138592 and rs6671533 in the intron region of USP24 were genotyped in 200 patients with sporadic PD and 200 healthy controls using the SNaPshot technique. Results There was significant difference in the allele and genotype frequency of rs12138592 between the patients and the controls (P<0.01), and no significant difference was found in the allele and genotype frequency of rs6671533 (P>0.05). Conclusion The SNP of rs12138592 in the intron region of USP24 is associated with the susceptibility to sporadic PD in the Han Guangdong population, and the A allele may contribute a protective roles to PD.