Expression and clinical significance of long chain non-coding RNA LOC285194 in human breast cancer tissue
10.3969/j.issn.1671-8348.2017.09.024
- VernacularTitle:长链非编码RNA LOC285194在乳腺癌组织中的表达及临床意义
- Author:
Qiuxia HUANG
;
Gang CHEN
;
Zhenbo FENG
;
Kanglai WEI
;
Hao CHEN
- Keywords:
breast neoplasms;
long chain non-coding RNA;
LOC285194;
tumorigenesis;
human epidermal growth factor receptor-2
- From:
Chongqing Medicine
2017;46(9):1223-1225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of long chain non-coding(lnc) RNA LOC285194 in breast cancer tissue and paracancerous tissue and its clinical significance.Methods Forty-two samples of paraffin embedded breast cancer tissue and 16 samples of paraffin embedded paracancerous tissue were selected.The expression of lncRNA LOC285194 in these tissue were detected by using quantitative real-time polymerase chain reaction(PCR).Then its correlation with clinicopathological features was analyzed.Results The expression level of lncRNA LOC285194 in breast cancer tissue was significantly lower that in the paracancerous tissue (P＜0.01);the level of lncRNA LOC285194 in human epidermal growth factor receptor-2(HER2)overexpression tissues was up-regulated compared with HER2 negative breast cancer tissue(P =0.013),there was a positive correlation between them(r=0.385,P=0.012).Conclusion lncRNA LOC285194 may play the role of cancer suppressor gene and may be involved in the generation of breast cancer by HER2 association,which may become a target gene of breast cancer treatment.
