Liver transplantation for patients with hepatopulmonary syndrome: long-term follow-up and prognosis analysis
10.3760/cma.j.issn.1007-8118.2017.03.001
- VernacularTitle:肝肺综合征患者肝移植术后长期随访结果和预后分析
- Author:
Jindan HE
;
Shipeng LI
;
Zhen WANG
;
Yao YU
;
Haiming ZHANG
;
Zilin CUI
;
Wenli YU
;
Zhijun ZHU
;
Hongyin DU
- Keywords:
Hepatopulmonary syndrome;
Liver transplantation;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(3):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive To analyze the clinical efficacy of liver transplantation (OLT) for patients with hepatopulmonary syndrome (HPS).Methods From 2008 to 2013,420 adult patients underwent liver transplantation in our hospital.There were 91 patients with,and 329 patients without,HPS.The 5-year survival and mortality rates after OLT for the two groups were retrospectively analyzed.Results There were no significant differences between patients without and with HPS in age,primary disease,Child-Pugh score,MELD score,cold ischemia time and warm ischemia time.However,the differences on serum albumin [(29.6 ± 1.2) g/L vs.(26.4 ± 1.6) g/L] and blood oxygen pressure [(61.0 ±9.0) mmHg (1 mmHg =0.133 kPa) vs.(87.0 ± 6.0) mmHg] were significantly different (P ＜ 0.05).The 1-year cure rate was 65.9％ (60/91) in 91 patients with HPS after liver transplantation.The 1,3,5-year cumulative survival rates for patients without HPS were 97.3％,90.9％ and 80.3％,respectively,and the main causes of death were primary graft dysfunction,recurrent cardiovascular events and primary disease recurrence or tumors.The 1,3,5-year cumulative survival rates for patients with HPS were 65.9％,59.3％ and 56.0％,and the main causes of death were multiple-organ failure,pulmonary infection and cerebrovascular events.Kaplan-Meier survival curve analysis showed that the survival of patients with HPS was significantly lower than that of patients without HPS (P ＜ 0.05).Conclusions Liver transplantation is the most effective treatment for patients with HPS,but the short-term mortality rate is relatively high.We still need to learn more about HPS to improve the survival rate of patients with HPS after liver transplantation.
