Effects of different concentrations of sevoflurane on left ventricular function
10.3760/cma.j.issn.0254-1416.2016.12.006
- VernacularTitle:不同浓度七氟醚对患者左心功能的影响
- Author:
Benhong HAN
;
Hong XIE
;
Chen WANG
- Keywords:
Anesthetics,inhalation;
Dose-response relationship,drug;
Heart function tests
- From:
Chinese Journal of Anesthesiology
2016;36(12):1435-1437
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different concentrations of sevoflurane on the left ventricular function of patients.Methods Forty patients of both sexes,aged 30-50 yr,with body mass index of 18-25 kg/m2,of American Society of Anesthesiologists physical status Ⅰ,were divided into Ⅰ,Ⅱ,Ⅲ,and Ⅳ groups (n =10 each) using a random number table.The end-tidal concentration of sevoflurane was set at 2％,3％,4％ and 5％ in Ⅰ,Ⅱ,Ⅲ and V groups,respectively.The parameters of left ventricular function were monitored using the ultrasonic cardiogram.Before induction of anesthesia (T0,baseline) and at 3,5,8 and 10 min after the end-tidal concentration of sevoflurane reached the target concentration (T1-4),the left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular ejection fraction (LVEF),left ventricular fractional shortening,cardiac output (CO) and heart rate (HR) were recorded.Results The LVEF,CO and HR were within the normal range.Compared with those at T0,the LVEF,left ventricular fractional shortening and CO were significantly decreased at T2-4 in Ⅱ-Ⅳ groups,the left ventricular end-systolic diameter was increased at T2-4 in Ⅲ and Ⅳ groups (P＜0.05),no significant change was found in the left ventricular end-diastolic diameter and HR at each time point in Ⅲ and Ⅳ groups,and no significant change was found in the parameters mentioned above in group Ⅰ (P＞0.05).Conclusion Inhaling 2％ sevoflurane produces no marked effect on the left ventricular function,3％-5％ sevoflurane exerts inhibitory effect on the left ventricular systolic function,and has no effect on the left ventricular diastolic function of patients.
