Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer
- VernacularTitle:多模式镇痛对结肠癌根治术患者细胞因子及皮质醇水平的影响
- Author:
Jianzhi YANG
;
Yan YU
;
Chongya HANG
- Keywords:
Multimodal analgesia;
Cortisol;
Inflammatory factors;
Radical colon cancer surgery
- From:
Journal of Kunming Medical University
2016;37(9):116-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of multimodal analgesia on cytokines and cortisol levels in patients received surgical treatment for radical colon cancer.Methods Eighty-six patients with radical colon cancer treated with surgery were randomly divided into control group and observation group.The control group only received routine epidural anesthesia and the observation group received multimodal analgesia.Preoperative and postoperative VAS scores,cytokines and cortisol levels were measured.Results Compared with those of the control group,the following 5 indicators decreased significantly in the observation group including VAS scores of after 24 h,48 h,72 h,IL-8 and TNF-α after 24 h,IL-6,IL-8 and TNF-α after 48 h,Cor after 24h,and Cor and ACTH after 48 h (P＜0.05).Conclusion Perioperative multi-mode analgesia helps relieve pain,stress and inflammatory cytokines among patients after the surgery for radical colon cancer.
