The Role of FUS/TLS in the Regulation of Gene Expression and the Correlation with Neurodegenerative Diseases
- VernacularTitle:FUS/TLS在基因表达调控中的作用及与神经退行性疾病的关系
- Author:
Pu HUANG
;
Guoping LI
- Keywords:
FUS/TLS;
Neurodegenerative diseases;
Gene expression regulation
- From:
Journal of Kunming Medical University
2016;37(8):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are chronic lesions caused by neuronal degeneration and secondary demyelination.Recent studies have shown that a DNA/RNA binding protein named fused in sarcoma/translocated in liposarcoma protein (FUS/TLS) is associated with neurodegenerative diseases,such as amyotrophic lateral sclerosis (ALS),frontotemporal dementia (FTD) and polyglutamine diseases.Mutations or dysfunction in FUS/TLS are responsible for the abnormal processes in the related gene transcription,RNA processing,transportation and translation and are highly correlated with the development of neurodegenerative disease.Discovery and the research of FUS/TLS not only contribute to the understanding of neurodegenerative disease at RNA level,but also provide a new way for the prevention and treatment of neurodegenerative diseases.
