Advances in the research of staphylococcus aureus accessory gene regulator system dysfunction
10.3760/cma.j.issn.1673-4408.2017.02.006
- VernacularTitle:金黄色葡萄球菌附属基因调节系统功能缺陷的研究进展
- Author:
Xin YANG
- Keywords:
Staphylococcus aureus;
Accessory gene regulator system
- From:
International Journal of Pediatrics
2017;44(2):94-98
- CountryChina
- Language:Chinese
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Abstract:
Staphylococcus aureus continues to be a major pathogen in both community and healthcare associated infections.The pathogenicity of staphylococcus aureus is a complex process involving a variety of extracellular and cell wall components that are coordinately expressed during different stages of infection.Accessory gene regulator (agr)-mediated quorum sensing plays a major role in staphylococcal pathogenesis.However,agr dysfunction strains exist extensively in staphylococcus aureus clinical isolates.This review will mainly focus on the influence of agr dysfunction on staphylococcus aureus biofilm formation,clinical course and outcome of infectious diseases,and antibiotic resistance.
