Ryanodine receptor phosphorylation in sepsis-induced cardiomyopathy
10.3760/cma.j.issn.1673-4408.2017.02.005
- VernacularTitle:兰尼碱受体磷酸化在脓毒性心肌病中的作用
- Author:
Yangehui PAN
- Keywords:
Sepsis;
Cardiac dysfunction;
Ca2 + channel;
Ryanodine receptor
- From:
International Journal of Pediatrics
2017;44(2):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a systemic inflammatory reaction caused by infection,which is a common complication after bum,serious trauma,major surgery,pathological obstetrics,toxication and cardiopulmonary resuscitation.Simultaneously,it's also an important cause which can lead to septic shock and multiple organ dysfunction syndrome.Heart is the target of multiple organ dysfunction caused by sepsis,leading to different degrees of cardiac dysfunction by sepsis and vice verse.Ryanodine receptor is macromolecule composed by complex protein structure,which is the major component of Ca2+ channels.It's the necessary factor to adjust muscle,cardiac rhythm and contraction.It is also involved in regulating sarcoplasmic reticulum to release Ca2+.This article is to give a review of ryanodine receptors in cardiac dysfunction caused by sepsis.
