Mitochondrial fusion and fission in the pathogenesis of sepsis
10.3760/cma.j.issn.1673-4408.2017.02.004
- VernacularTitle:线粒体融合-分裂在脓毒症发病机制中的作用
- Author:
Zhongyuan SUN
- Keywords:
Sepsis;
Mitochondrial fusion and fission
- From:
International Journal of Pediatrics
2017;44(2):85-89
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a systemic inflammatory response syndrome caused by infection,and further development can lead to septic shock and multiple organ dysfunction syndrome.Clinical research of sepsis morbidity and mortality is a hot topic in this field.Subcellular related studies in recent years show that mitochondrial damage plays a very important role in the development of sepsis,especially septic shock.Mitochondria are highly dynamic organelles in the cell.They continue to merge and divide within cells,forming a dynamic equilibrium network structure.In sepsis,imbalance of mitochondrial fusion and fission leads to disorders of the intracellular molecules,cells,and organs.This article reviews the progress in the investigation of mitochondrial fusion and fission in the pathogenesis of sepsis.
