Status and clinical value of microsatellite instability in stage Ⅱ colon cancer
10.3760/cma.j.issn.1007-631X.2017.02.015
- VernacularTitle:Ⅱ期结肠癌组织中微卫星不稳定状态及其与患者预后的关系
- Author:
Yunfeng YAO
;
Nan CHEN
;
Changzheng DU
;
Jin GU
- Keywords:
Colonic neoplasms;
Microsatellite instability;
Prognosis;
Pathology,clinical
- From:
Chinese Journal of General Surgery
2017;32(2):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic value of microsatellite instability (MSI) in stage Ⅱ colon cancer patients.Methods 120 stage Ⅱ colon cancer patients underwent radical resection in the Department of Colorectal Surgery,Beijing Cancer Hospital from 2000 to 2007.Tissue samples were collected and DNA was extracted for MSI determination using PCR following the Pentaplex panel.Clinical parameters were also combined and analyzed statistically to explore the association between MSI status and clinical parameters.Results The incidence of high frequency of microsatellite instability (MSI-H) was 20.8％ in these 120 stage Ⅱ colon cancer patients.There was a significant correlation between the status of MSI and tumor differentiation (x2 =9.69,P =0.021);However MSI status was demonstrated to be a prognostic factor for disease free survival or overall survival (all P ＞ 0.05).Nor was MSI status associated with tumor relapse or metastasis.Age and preoperative serum CEA level were identified as independent factors for DFS by Cox regression.Conclusion In stage Ⅱ colon cancer patients,MSI status correlates with tumor differentiation,but is not a prognostic factor.
