Analysis of adverse drug reactions in multidrug-resistant pulmonary tuberculosis patients
10.3760/cma.j.issn.1000-6680.2017.02.005
- VernacularTitle:耐多药肺结核患者抗结核药物所致不良反应发生情况
- Author:
Fei WANG
;
Bin CHEN
;
Lin ZHOU
;
Ying PENG
;
Mingwu ZHANG
;
Yu ZHANG
;
Xiaomeng WANG
- Keywords:
Tuberculosis;
pulmonary;
Tuberculosis;
multidrug-resistant;
Therapy;
Adverse drug reactions
- From:
Chinese Journal of Infectious Diseases
2017;35(2):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the adverse drug reactions (ADR) during the standardized treatment of multidrug-resistant pulmonary tuberculosis (MDR-PTB), and to evaluate its impact on treatment outcomes.Methods A retrospective study was carried out on 305 MDR-PTB patients.Medical records of clinical treatment and laboratory examinations were collected, and the ADR data were analyzed.Chi-square test or Fisher exact test was used for discontinuous variables, and t test or non-parametric test was used for continuous variables.Results Among 305 MDR-PTB patients , 282 (92.5%) had at least one ADR.The major ADR were gastrointestinal reaction (46.9%), thyroid dysfunction (41.3%), hypokalemia (34.1%), renal injury (29.8%), hematological system impairment (21.6%), hepatotoxicity (19.0%), arthralgia or courbature (11.1%), and ototoxicity and vestibular dysfunction (8.5%).Sex, age, native place, the history of using second-line TB drugs or the history of diabetes mellitus had no significant effect on the incidence of ADR (all P>0.05).As per the Naranjo causality assessment of ADR, 34 patients had definite, 236 had probable, 12 had possible and 0 had doubtful causal relations.Among the 282 cases with ADR, 175 (62.1%) patients continued the original treatment regimen, 89 (31.6%) patients changed or stopped ADR-related drugs, only 18 (6.4%) cases stopped MDR-PTB treatment.The episodes of ADR had no significant effect on the treatment outcomes (P>0.05).Conclusions Although ADR are common in MDR-PTB patients during the treatment course, most of the ADR can be managed.Through timely monitoring and appropriate treatment of ADR, most of the patients could continue MDR-PTB treatment.
