Recent advances in vivo model of lumbar disc degeneration
10.3969/j.issn.2095-4344.2017.11.026
- VernacularTitle:体内腰椎间盘退变动物模型的研究与进展
- Author:
Sheng MA
;
Yusong JIA
;
Qi SUN
- From:
Chinese Journal of Tissue Engineering Research
2017;21(11):1790-1797
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Establishment of lumbar disc degeneration in animal models can help doctors understand the development rules and pathophysiological changes of this disease, and can explore and research more rational treatment by creating animal models.OBJECTIVE: To review recent advances in vivo model of lumbar disc degeneration.METHODS: The first author used the computer to search related articles on PubMed database and Chinese Journal Full-text Database from inception to May 2016. The search key words were lumbar disc, degeneration, animal model,vivo model. A total of 161 related articles were retrieved and 49 of them met the inclusion criteria.RESULTS AND CONCLUSION: (1) Building an intuitive and reliable animal model of lumbar disc degeneration will not only help the basic research of degenerative disc disease, but also provide a good experimental carrier for the repair treatment of degenerative lumbar disc. (2) After more than 80 years of development, the animal model of lumbar disc degeneration has formed a production mode of more species, more methods and newer ideas. Current models have their own advantages, cannot be replaced. However, problems such as poor controllability, low degree of safety or long observation period are still exiting more or less. All these need further research and exploration.
