Wallerian degeneration after peripheral nerve injury: research advance in nerve conduits
10.3969/j.issn.2095-4344.2017.10.020
- VernacularTitle:周围神经损伤后瓦勒氏变性及神经导管的研究与进展
- Author:
Biao CHANG
;
Qi QUAN
;
Xun SUN
;
Ruoxi LIU
;
Yu WANG
;
Shibi LU
;
Jiang PENG
- From:
Chinese Journal of Tissue Engineering Research
2017;21(10):1596-1603
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: How to promote the regeneration after peripheral nerve injury, especially after large defects, is a difficulty to be solved.OBJECTIVE: To review the mechanism of Wallerian degeneration and the development of nerve conduits.METHODS: PubMed database was searched for the literatures addressing the modular mechanism of Wallerian degeneration and nerve repair using the English keywords peripheral nerve regeneration, Wallerian degeneration, nerve guidance conduits. A total of 74 eligible literatures were included based on the exclusion criteria.RESULTS AND CONCLUSION: Rat SARM1 and fruit fly dSARM have been found to be highly implicated in Wallerian degeneration, indicating that the changes of nicotinamide adenine nucleotide/nicotinamide adenine dinucleotide may be related to the activated SARM1. Whether delaying Wallerian degeneration is good or bad is still in dispute. The future study should focus on the early inhibition of Wallerian degeneration and promotion of neuroregeneration following peripheral nerve injury.
