Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis.
10.3341/kjo.2014.28.3.207
- Author:
Francisco Javier JIMENEZ-BALDERAS
1
;
Janete GARCIA-JAIMES
;
Rita RIOS
;
Abraham ZONANA-NACACH
;
Raquel TAPIA-ROMERO
;
Nayeli VILLANUEVA
;
Patricia MENDEZ-SAMPERIO
;
Jorge Luis DE-LA-ROSA-ARANA
Author Information
1. Rheumatology Department, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico.
- Publication Type:Original Article
- Keywords:
Ankylosing-spondylitis;
Anterior-uveitis;
Toxocariasis
- MeSH:
Acute Disease;
Adult;
Aged;
Animals;
Antibodies, Anti-Idiotypic/*isolation & purification;
Enzyme-Linked Immunosorbent Assay;
Eye Infections, Parasitic/complications/*immunology/parasitology;
Female;
Humans;
Immunoglobulin G/*immunology;
Male;
Middle Aged;
Seroepidemiologic Studies;
Spondylitis, Ankylosing/*complications/immunology/parasitology;
Toxocara canis/*immunology/isolation & purification;
Toxocariasis/complications/*immunology/parasitology;
Uveitis, Anterior/complications/*immunology/parasitology;
Young Adult
- From:Korean Journal of Ophthalmology
2014;28(3):207-212
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU. METHODS: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions. RESULTS: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS. CONCLUSIONS: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
