Analysis for Relevant Clinical Parameters and Biomarkers in Patients of Essential Hypertension Combining Acute Coronary Syndrome
10.3969/j.issn.1000-3614.2017.04.012
- VernacularTitle:高血压患者发生急性冠状动脉综合征相关临床和生化标记物因素分析
- Author:
Chunlin LAI
;
Jinping XING
;
Xiaohong LIU
;
Jie QI
;
Jianqiang ZHAO
;
Yourui JI
;
Wuxiao YANG
;
Pujuan YAN
;
Chunyan LUO
;
Lufang RUAN
- Keywords:
Hypertension;
Acute coronary syndrome;
Inflammatory factors
- From:
Chinese Circulation Journal
2017;32(4):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the relationship between inflammatory factors and relevant risk factors in patients of essential hypertension (EH) combining acute coronary syndrome (ACS) with its clinical significance. Methods: Our research included 3 groups: EH group, n=79 patients with standard criteria, EH+ACS group, n=85 and Control group, n=48 normal subjects. Blood levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), tryptase (TPS) and relevant clinical, biochemical parameters were measured; risk factors for cardiovascular disease were examined and the relationship between above parameters, risk factors and ACS occurrence in EH patients was studied by Logistic regression analysis. Results: The OR values were all greater than 1 in fibrinogen (Fbg), high-sensitivity C-reactive protein (hs-CRP), TPS, atherosclerotic plaque, Lp-PLA2 and EH grading. Fbg was the most significant independent risk factor (OR=22.242, 95% CI 6.458-76.609, P<0.0001), the standardized partial regression coefficient b'as absolute value (b') was 1.079 which was the highestone in above 6 variables with the strongest impact for ACS occurrence in EH patients. Conclusion: Fbg, hs-CRP, TPS, atherosclerotic plaque and EH grading were the independent risk factors for ACS occurrence in EH patients; Fbg was the highest risk factor for ACS occurrence with the strongest impact, which provided a new direction for ACS prevention and treatment.
