Oxygen Uptake Efficiency Slope Predicting the Prognosis in Patients With Idiopathic Pulmonary Arterial Hypertension
10.3969/j.issn.1000-3614.2017.04.014
- VernacularTitle:摄氧效率斜率预测特发性肺动脉高压预后
- Author:
Yi TANG
;
Qin LUO
;
Zhihong LIU
;
Chenhong AN
;
Xiuping MA
;
Zhihui ZHAO
;
Zhiwei HUANG
;
Qing ZHAO
;
Hongliang ZHANG
;
Yong WANG
;
Liu GAO
;
Xue YU
;
Qi JIN
;
Changming XIONG
;
Xinhai NI
- Keywords:
Oxygen uptake efficiency slope;
Exercise test;
Hypertension;
pulmonary
- From:
Chinese Circulation Journal
2017;32(4):367-371
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To explore weather oxygen uptake efficiency slope (OUES) may predict the prognosis in patients with idiopathic pulmonary arterial hypertension (IPAH). Methods: The consecutive newly diagnosed IPAH patients in our hospital from 2010-11 to 2015-06 were prospectively enrolled and regular follow-up study was conducted to record cardiovascular events (death and lung transplantation). Kaplan–Meier curve, uni- and multivariate Cox regression analysis were performed to assess the survival rate in relevant patients. Results: A total of 210 IPAH patients at the mean age of (32±10) years were finished cardiopulmonary exercise test (CPET) and received regular follow-up study including 159 female. There were 31 patients died and 1 received lung transplantation over 41 months follow-up period. OUES was positively related to peak oxygen uptake (VO2)/body weight (r=0.71, P<0.0001). Multivariate analysis demonstrated that OUESI and NT-proBNP could independently predict the prognosis of IPAH patients. The 5-year survival rate in patients with OUESI≤0.52 L/(min?m2) was lower than those with OUESI>0.52 L/(min?m2) (41.9% vs 89.8%), P<0.0001.Conclusion: OUES as a submaximal CPET parameter may well predict the prognosis in IPAH patients.
