Impact of Valsartan on Sarcoplasmic Reticulum Ryanodine Receptor2 in Myocardiocyte of Heart Failure Rabbits
10.3969/j.issn.1000-3614.2017.04.019
- VernacularTitle:缬沙坦对心力衰竭家兔心肌细胞肌浆网兰尼碱受体的影响
- Author:
Fuzheng QU
;
Xiaolu ZHANG
;
Jingwu SUN
;
Xianliang LIU
;
Dong WANG
;
Mengsong SHI
;
Xiuhua WANG
;
Aiyan QU
;
Xinlei LU
;
Hongxia ZHOU
;
Lin CHENG
;
Haofei KANG
;
Xiaorui YI
;
Jing LIU
- Keywords:
Heart failure;
Sarcoplasmic reticulum;
Ryanodine receptor calcium release channel
- From:
Chinese Circulation Journal
2017;32(4):390-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore sarcoplasmic reticulum ryanodine receptor2 (RyR 2) expression and calcium releasing function in chronic heart failure (CHF) rabbits and to study the impact of long term valsartan treatment in relevant animals. Methods: HF model was established by volume overloading with pressure overloading in experimental rabbits. 27 rabbits were divided into 3 groups: Sham group, HF group and HF+valsartan group. n=9 in each group and the animals were treated for 7 weeks. Left ventricular structure, hemodynamic parameters, expression and functional changes of myocardiocyte sarcoplasmic reticulum RyR 2 were observed and compared among different groups. Results: Compared with Sham group, HF group had increased left ventricular mess index (LVMI), left ventricular end diastolic pressure (LVEDP) and decreased left ventricular shortening fraction, LVEF, all P<0.05. Compared with HF group, HF+valsartan group showed decreased LVMI, LVEDP and increased left ventricular shortening fraction, LVEF, all P<0.05. Sarcoplasmic reticulum RyR 2 expression and calcium releasing function were lower in HF group than Sham group, P<0.05; while they were both higher in HF+valsartan group than HF group, P<0.05. Conclusion: Long term application of valsartan could improve the cardiac function which might be related to increased myocardial sarcoplasmic reticulum RyR 2 expression and calcium releasing function in experimental CHF rabbits.
