Study on registrations of clinical trials of tumor necrosis factor α antagonist
10.3969/j.issn.1000-484X.2017.04.021
- VernacularTitle:TNF-α拮抗剂临床试验注册现状
- Author:
Qunyan ZHANG
;
Junhao GUO
;
Hui CAI
- Keywords:
Tumor necrosis factor α;
Biological agents;
Clinical trials;
Data collection
- From:
Chinese Journal of Immunology
2017;33(4):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize and analyze the clinical status of tumor necrosis factor-α (TNF-α) antagonists.Methods: The clinical trials of TNF-α antagonists registered before August 2,2016 were searched on the National Institutes of Health (NIH) Clinical Trials Register,and SPSS17.0 software was used for statistical analysis of the data.Results: A total of 306 TNF clinical trials were conducted in the world,19 of them were in China.The main research diseases for bone and joint disease,autoimmune diseases,infections,blood tumors.There were 241 items in intervention study,and 56,7,55,60 items in 178 cases,accounting for 73.9% in Ⅱ,Ⅱ/Ⅲ,Ⅲ,Ⅳ,respectively.The interventional study of TNF-α antagonist clinical trials mainly focused on intervention research,The main purpose of the practical application of the process after the listing of further validation and evaluation of drug efficacy and safety.Conclusion: There are many kinds of TNF-α antagonists,and clinical indications are wide.The design of clinical trials is diversified and mature.
