Correlation analysis between EMT and progression of chronic obstructive pulmonary disease (COPD) and its related non-small cell lung cancer (NSCLC)
10.3969/j.issn.1000-484X.2017.04.025
- VernacularTitle:慢性阻塞性肺病及其相关非小细胞肺癌进程与EMT的相关性研究
- Author:
Fen CHANG
;
Guihua XIAO
;
Qi LI
;
Jin YANG
- Keywords:
Chronic obstructive pulmonary disease;
NSCLC;
EMT;
Relevance
- From:
Chinese Journal of Immunology
2017;33(4):598-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Based on relevant database data analysis,to explore the correlation of the abnormal expression of EMT related factors and chronic obstructive pulmonary disease and its related non-small cell lung cancer.Methods: Based on some data sets of GEO in the NCBI database,to perform express analysis,survival analysis and correlation analysis.Results: ①Snai1 and other EMT related regulatory factors exist significantly higher expression in non-small cell lung cancer patients,and E-cadherin (CDH1) was showed significantly lower expression. ②A large number of COPD patients samples were analyzed,and some EMT-related molecules in patients with COPD also showed significant abnormal expression and consistented with the changes in patients with non-small cell lung cancer.Conclusion: The results showed that dysregulation expression of EMT related regulatory factors may have some correlation with disease progression of COPD patients through the EMT markers and their expression and correlation analysis in COPD patients.
