Radio-nuclear Imaging Study on Coronary Collateral Circulation and Myocardial Viability in Patients With Chronic Total Occlusion of Left Anterior Descending Artery
10.3969/j.issn.1000-3614.2017.04.009
- VernacularTitle:冠状动脉左前降支慢性完全闭塞病变中侧支循环与心肌存活的心肌放射性核素显像研究
- Author:
Shuheng LI
;
Wei FANG
;
Xiaoxin SUN
;
Yueqin TIAN
;
Rui SHEN
;
Feng GUO
;
Qi WANG
;
Zuoxiang HE
- Keywords:
Coronary artery disease;
Collateral circulation;
Myocardial perfusion imaging;
Myocardial metabolism imaging
- From:
Chinese Circulation Journal
2017;32(4):343-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the effect of coronary collateral circulation (CCC) on myocardial viabilityin patients with chronic total occlusion of left anterior descending (LAD) artery. Methods: A total of 101 consecutive patients with confirmed diagnosis of total LAD occlusion in our hospital were enrolled. Rest 99mTc-MIBISPECT myocardial perfusion and 18F-FDG PET were performed, in addition all patients received coronary angiography (CAG) at 3 months front and back. Both images were reconstructed in the same machine and QPS software was used to obtain the summed rest score (SRS), abnormal resting total perfusion defect (TPD), viable and non-viable myocardium, LVEDV, LVESV and LVEF in relevant patients. Based on CAG result, the patients were divided into 2 groups: CCC group, n=39 and No CCC group, n=62; according to existing old myocardial infarctionand location of LAD occlusion, the patients were further divided into 4 subgroups. The above parameters were compared among different groups. Results: There were 86 male and 15 female patients with the mean age at (59.92±11.43) years. Relevant parameters in CCC group and No CCC groupwere as in SRS: (21.23±9.68) vs (28.56±8.76), TPD: (30.03±13.69) %vs (40.37±12.50) %, viable myocardium: (21.77±13.12) % vs (13.66±9.23) %, non-viable myocardium (8.28±8.58) %vs (27.40±12.97) %, all P<0.05; in LVEDV: (109.82±30.01) ml vs (173.71±57.69) ml, LVESV: (62.82±22.39) ml vs (122.53±51.66) ml, LVEF: (43.85±8.46) % vs (31.03±8.30) %, all P<0.05. Conclusion: Our preliminary study found that CCC could maintain left ventricular rest perfusion, myocardial viability and protect cardiac function in patients with chronic total LAD occlusion.
