Co-expression network and function analysis of TP53 and NOTCH1 in head and neck squamous cell carcinoma
10.11659/jjssx.11E016055
- VernacularTitle:头颈部鳞癌中TP53和NOTCH1基因的共表达网络及功能分析
- Author:
Yanqiu ZHENG
;
Feifei ZHAO
;
Xiaobo CUI
;
Wenliang HU
;
Xuewei SUN
- Keywords:
head and neck squamous cell carcinoma;
TP53;
NOTCH1;
co-expression network
- From:
Journal of Regional Anatomy and Operative Surgery
2017;26(3):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the expression relation between TP53 and NOTCH1,and to explore their effects in head and neck squamous cell carcinoma.Methods Obtained the differentially expressed genes data of head and neck squamous cell carcinoma from 279 samples in TCGA database.Analyzed the co-expression relation between TP53 and NOTCH1 through Pearson and Spearman method.Cbioportal was used to analyze their co-expressed genes.Establish the co-expression network of TP53 and NOTCH1 with String database.The pathway and function of co-expression network was identified through KEGG and DAVID database respectively.Results Among the 279 samples,TP53 and NOTCH1 was co-expressed in head and neck squamous cell carcinoma.(Pearson score =0.45;Spearman score =0.41) There were 182 interaction pairs of TP53 and NOTCH1 related co-expressed gene according to the String database.(Pearson and Spearman score ＞ 0.3)These genes were enriched in some pathways such as T cell receptor signaling pathway,cell cycle,cell adhesion molecules and so on.These genes were enriched in some tumor related function including immune response,regulation of transposition,regulation of apoptotic process,cell cycle,regulation of GTPase activity and so on.Conclusion TP53 and NOTCH1 was co-expressed.Through establishing co-expressed network of TP53 and NOTCH1 and bioinformatics analysis,their function and signaling pathway were explored.The data generated from this study could provide a new reference in mechanism research of head and neck squamous cell carcinoma.
