Brain functional magnetic resonance imaging characteristics induced by olfactory stimulations in healthy adults
10.3760/cma.j.issn.1006-7876.2017.04.011
- VernacularTitle:嗅觉刺激健康成年人诱发的脑功能磁共振成像初步研究
- Author:
Xiaoyan ZHOU
;
Cheng LUO
;
Xiaoming WANG
;
Changyue HOU
;
Yaodan ZHANG
;
Juan TAN
;
Fei YANG
- Keywords:
Adult;
Olfactory perception;
Magnetic resonance imaging;
Brain
- From:
Chinese Journal of Neurology
2017;50(4):288-291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the features of activation mapping induced by olfactory stimulation with functional magnetic imaging (fMRI), which will help to reveal the neural mechanism of olfactory dysfunction and contribute to the earlier diagnosis and treatment of neural degenerative disorders.Methods In this prospective study, 21 healthy volunteers were recruited in the Affiliated Hospital of North Sichuan Medical College from March to October 2015.Olfactory function was evaluated by using Visual Analogue Scale (VAS).During the fMRI scanning, all subjects received olfactory stimulation of rose and lavender odor.The brain activation was obtained by using softwares matlab2008a and SPM8.Results All subjects had normal olfactory function evaluated by VAS score (4.86±0.07).The activated brain areas included: bilateral inferior parietal lobule, bilateral inferior frontal gyrus-orbitofrontal gyrus, left insula, bilateral inferior temporal gyrus, left putamen, bilateral hippocampus, bilateral cingulate cortex, bilateral piriform cortex, bilateral amygdale, left lingual gyrus, bilateral cerebellum (t=2.62, P<0.01).Conclusions Olfactory is associated with multiple brain regions.The combination of olfactory event-related design and fMRI, as an objective measurement of olfactory, can be applied to investigate the olfactory cortical brain mapping.
