Progress in researches on exosomes in non-small cell lung cancer
- VernacularTitle:外排体在非小细胞肺癌中的研究进展
- Author:
Kaidi LI
;
Wenzhe LI
;
Ling ZHU
;
Yanlian YANG
;
Naixin LIANG
;
Shanqing LI
- Keywords:
exosome;
non-small cell lung cancer;
clinical trials;
biomarker;
liquid biopsy
- From:
Basic & Clinical Medicine
2017;37(4):561-566
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are vesicle-like structures generated and secreted actively by all kinds of cells.They contain proteins, nucleic acids and also lipids from the original cells, functioning in interactions between cells by shuttling cellular cargoes, and regulation of immune response in the microenvironment.Besides, they play important roles in the oncogenesis and progression of lung neoplasms.Considerable studies have demonstrated great potentials of exosomal proteins and microRNAs as biomarkers for diagnosis, prognosis prediction and treatment of lung cancers, including immunotherapy and targeted delivering of anti-tumor drugs based on exosomes.
