The value of diffusion weighted imaging based on mono-exponential and bi-exponential model in evaluating the expression of vascular endothelial growth factor
10.3969/j.issn.1002-1671.2017.04.017
- VernacularTitle:单、双指数模型DWI评价胃癌血管内皮生长因子的价值
- Author:
Zhaohui QU
;
Xuemei GAO
;
Jingliang CHENG
;
Yubo LI
;
Yuncai RAN
- Keywords:
gastric carcinoma;
diffusion weighted imaging
- From:
Journal of Practical Radiology
2017;33(4):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the apparent diffusion coefficient(ADC) value of mono-exponential diffusion weighted imaging(DWI) and the true diffusion coefficient(D) value, related diffusion coefficient(D*) value, perfusion fraction (f) value of bi-exponential model DWI in reflecting the expression of vascular endothelial growth factor (VEGF).Methods Using immunohistochemical staining method to detect VEGF expression in the 28 cases of gastric carcinoma tissue section and the surrounding normal gastric tissue.The differences of ADC value, D value, D* value, f value in different VEGF expression grading and gastric carcinoma classification were analyzed respectively.Results The differences of ADC value, D value, f value between different VEGF grading were statically significant,as the higher VEGF grading accompanied wth the lower ADC values, D value and the higher of f value;and the differences of the parameters between high and low differentiated gastric carcinoma were also statically significant (P<0.05).Conclusion The ADC value of mono-exponential DWI and the D value,f value of bi-exponential model DWI could evaluate the expression of VEGF and reflect the gastric carcinoma angiogenesis.
