Remodeling of Skeletal Muscle Extracellular Matrix and Insulin Resistance (review)
10.3969/j.issn.1006-9771.2017.04.007
- VernacularTitle:骨骼肌细胞外基质重塑与胰岛素抵抗的研究进展
- Author:
Yanan YANG
;
Junjun Lü
;
Ke WANG
;
Dongmei LIU
- Keywords:
insulin resistance;
extracellular matrix;
skeletal muscle;
fibrosis;
integrin;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(4):398-401
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle extracellular matrix (ECM) is the microenvironment for muscle cells to survive and function. Changes in ECM components and structure directly affect the activity and function of muscle cells. Pathological remodeling occurs to skeletal muscle ECM in insulin resistance, including collagen deposition, hyaluronan accumulation, activation of membrane protein integrin signaling path-way, and the imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases, while all those would impair the tissue insu-lin sensitivity.
