Relationships between seven single nucleotide polymorphisms and female breast cancer among Hui and Han nationalities

VernacularTitle:回、汉族女性乳腺癌与7个单核苷酸多态性的关联研究
Author: Jing WANG ; Wenjun YANG ; Zanlin MA ; Fang ZHAO ; Lan LIU
Keywords: breast neoplasms; single nucleotide polymorphisms; Hui nationality; Han nationality
From:Military Medical Sciences 2017;41(3):190-193
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationships between seven single nucleotide pdymorphisms(SNPs), including 6788895(SIAH2 gene), rs10941679(5p12), rs889312(MAP3K1), rs13387042(2q35), rs6504950(17q23), rs17530068(6q14) and rs2284378(20q11), and female breast cancer of Hui and Han nationalities.Methods A hospital-based case-control using age and nationallity as frequency matching conditions was conducted in Affiliated General Hospital of Ningxia Medical University.Results ①A total of 225 breast cancer patients and 225 controls were enrolled in this study.There was no significant differentce between case group and control group in age(48.27±9.27 vs 48.48±9.36, t=0.238,P=0.812) or nationallity (181 Han people and 44 Hui people vs 184 Han people and 41 Hui people, x2=0.131, P=0.718).②The subjects of study conformed to Hardy-Weinberg equilibrium principles.③The genotype and allele distribution of the above seven SNPs were not significantly different between cases group and control group of Hui and Han nationalities.Conclusion The seven SNPs mentioned above may not be related to breast cancer among people Hui and Han nationalities.